We scale up production processes

●   Since our establishment in 2010, we have been scaling up production of new & complex molecules.

●   In 2022, we tripled our capacities and modernized our facilities with the launched our new site.

●   We focus on our goals for EHS, scale, competitiveness and sustainability, by:

    ●   Optimizing solvents, reagents and catalysts

    ●   Minimizing reaction volumes, time and wastes.

    ●   “Green technologies”, among other initiatives.

 

What distinguishes us:

●    Team: Highly experienced in scale-ups and custom production, and long term committed.

●    Site: Fully compliant with EHS, QA, and CSR standards, equipped with ample capacity and open to audits.

●    14 years of an impeccable track record: efficient, competitive, and award-winning.

●    Track Record: 14 Years’ spotless & award-wining in custom-synthesis, Always in SPEC, on time, in full, and consistent.

●    Rapid access to a diverse range of chemical capabilities and expertise.

●    Deliverable under MSA:

    ●   Original MBRs and Analytical Procedures

    ●   Reports, Records, Raw Data with data-integrity.

    ●   Raw materials origins

●   And more.

 

Site Layout

 

 

Quality, Capacity, Safety, Sustainability

Subject	Description
Quality System and Facility Standard	Q7A GMP Guidance, for RSM & Pharma Intermediates production
Workshops	2 workshops, 3 floors of 2072 sqm each.
Number & sizes of reactors	92 in workshops (200L~5000L), ~20 in kilo labs (10L~100L)
Total Reaction Volume	150 M3
Production Safety	(1) Automatic Fire Suppression for production & storage areas; (2)Digital Control System: (2.1) Computerized accuracy for all critical steps & Minimized Human Exposure; (2.2) Automatically safeguards production; (3) Safety Interlocking System; (4) Fire-fighting Center; (5) Low Explosion Limit Gas Detecting
Sustainability	On site of "Yaojiagang Chemical Park”, which has been designated by China Central Government as a key park to support since June 2017. See a video by China National TV on July 27, 2022: http://tv.cctv.com/2022/07/27/VIDEwjEGPx3oivK7tGub3aoq220727.shtml (Park’s "EHS" & "Green“ @ 1m12s, & 3 visits to Hubei by President "Xi Jinping" as endorsement @0m44s, 2m28s).
Kilo Labs	5 Kilo Labs in One Dedicated Building: 2 x 60sqm, 2 x 120sqm and 1 x 170sqm (two stories to allow column distillation.)

 

 

Production Facilities

Two workshops in one building, total 3 floors, 2072 sqm each floor.	Inside workshops: reactors	300L Reactor + 10.5m Distillation Tower 3000L Reactor + 7.5m Distillation Tower	Clean room centrifuge
Dedicated building for Kilo Labs	Glass Reactors inside Kilo Labs	Low Temperature Reactor	Workshops: Clean room tray dryer

 

 

Production Auxiliary

Compressed Air & Nitrogen Generation	Purified Water System
Liquid Nitrogen Storage for “Cryogenic Reaction”: 1 x 5M3 + 1 x 2M3	DCS Center (Including DCS, SIS, LEL & Firefighting)

 

 

Equipment Lists for Production

Size	Reactor Type	QTY	Remark
200L	glass-lined	4	Each equipped with 4 temperature system: Stream, Heated Water, Tap-Water & Ice Brine, to ensure adequate control. Temperature -15 to 125 Deg/C
300L	glass-lined	4
500L	glass-lined	10
1000L	glass-lined	19
1500L	glass-lined	9
2000L	glass-lined	20
3000L	glass-lined	15
5000L	glass-lined	4
10-100L	Kilolab Glass Reactors	~20	Temperature -80 to 160 Deg/C, with microdistillation systems

Size	Reactor Type	QTY	Remark
200L	stainless steel	1	Cryogenic reactors, can reach: -85deg/C
500L	stainless steel	1
1000L	stainless steel	1
300L	glass-lined	1	With 10.5m distillation column
3000L	glass-lined	1	With 7.5m distillation column
500L	stainless steel	1	Temperature: -15 to 125deg /C.
Large	Tray drier	4	60trays each, vacuum, in workshop
Small	Tray drier	1	10 trays, under vacuum, in kilolab
1500L	Double-cone drier	2	Vacuum / N2 protection
1000mm	Centrifuge	6	Stainless steel, in workshop
450mm	Centrifuge	1	Stainless steel, in kilolab

 

 

Equipment List for Process R&D and Analysis

Building for Admin, Process R&D and QC	Analytical Lab, HPLC
Analytical Lab, HPLC & GC	Process R&D Labs

Equipment	QTY	Remarks
Desktop fume-hoods for Process R&D	17	1.8m width
Walk-In fume-hoods for Process R&D	2	1.8m width
Desktop fume-hoods for Q.C. Lab	1	1.8m width
Hydrogenation Autoclave	2	1 Liter
Agilent 7890-A	1	GC
Agilent 7890B	1	GC
Waters e2695	1	HPLC
Agilent 1260-01	1	HPLC
Agilent 1260-02	1	HPLC
Agilent 1260-03	1	HPLC

 

Chemical Expertise and Capabilities

Trusted & well connected since 1996, we have easy access to a big variety of specialized chemical capabilities, resources and expertise in Chinese industries, for our chemistry to excel beyond the boundaries of our own site:

At Our Own Site	At Our reliable Long-term Partner Sites:
Chlorination (Chlorine Gas, NCS, POCl3)	Hydrogenation (High Pressure)
Grignard Reaction	Nitration
Cryogenic reaction (-80deg/C, nBuLi/NaH)	Thiophosgene
Condensation Reaction	Fluorination (using “HF”, “KF”, Fluorine, Sulfur Tetrafluoride)
Cross-Coupling Reaction	Diazotization
Enzymatic Reaction	Flow Chemistry
Bromination (Br2, NBS, POBr3)	Cyanidation (NaCN, KCN, CuCN)
	Carbonyl insertion reaction (CO)
	Amination (NH3)

 

 

Site Qualification

ISO 9001	ISO 14001	ISO 45001